George Kittle will lead the San Francisco 49ers into their game versus the Buffalo Bills at Highmark Stadium on Sunday at ...

San Francisco has been up and down all season, but the Super Bowl hangover appears to be happening after the 49ers got ...

Christian McCaffrey and the 49ers travel to Buffalo to take on Josh Allen and the Bills for Sunday Night Football. Live ...

While the 49ers look like an easy opponent, San Francisco's health could be a major factor in the game, warns one NFL expert.

See who's in and who's out for the Week 13 matchup between the Buffalo Bills and San Francisco 49ers on December 1, 2024.

Following their bye week, the Bills (9-2) will take on the San Francisco 49ers (5-6) at Highmark Stadium in Week 13. But ...

The San Francisco 49ers may again be without starting quarterback Brock Purdy for their Week 13 clash with the San Francisco ...

The AFC East-leading Buffalo Bills return from their bye week to host the inconsistent San Francisco 49ers on Sunday night.

The 49ers have revealed their latest injury report from Wednesday’s practice before their Sunday Night Football tilt against ...

The Buffalo Bills Sunday night game against the San Francisco 49ers is shaping up to be a weather game as bitter cold air ...

The San Francisco 49ers are reeling and now head to Buffalo for a prime time game. Will they have their starting QB back in ...

Weather looks set to play a role in the Buffalo Bills' Week 13 matchup with the San Francisco 49ers.