Manny Machado drove in three runs against Justin Verlander and the San Diego Padres beat the San Francisco Giants 8-4 in a sloppy game.

A disastrous fifth inning doomed the Giants in San Francisco's 8-4 loss to the San Diego Padres on Thursday afternoon at Petco Park.

Bob Melvin did not hold back on how frustrating Thursday night was for the Giants in their loss to the Padres.

Manny Machado drove in three runs against Justin Verlander and the San Diego Padres beat the San Francisco Giants 8-4 on Thursday in a sloppy game. The Padres took three of four from the Giants and have won three straight going into a second straight weekend showdown against the defending World Series champion Los Angeles Dodgers.

Video replay controversy costs the Padres in a 4-3 loss to the Giants, as Xander Bogaerts' home run was overturned for fan interference despite the video showing otherwise.

The San Diego Padres took the series over the San Francisco Giants on Thursday, winning three of four games despite playing the entire set without star centerfielder Jackson Merrill. The 22-year-old exited Sunday’s game against the Los Angeles Dodgers early with a bone bruise in his left ankle, after initially tweaking it a couple of games prior.

BOTTOM LINE: The San Diego Padres face the San Francisco Giants on Wednesday. San Diego has a 70-56 record overall and a 39-21 record at home. Padres hitters are batting a collective .251, which ranks fourth in the NL.