Stock futures are pointing to a slightly lower open for major indexes on Wednesday as investors respond to a slew of earnings reports from retailers and brace for a big speech later in the week by Federal Reserve Chair Jerome Powell.

S&P 500 futures are down 0.3%. Dow Jones Industrial Average futures are dipping 0.3%. Nasdaq 100 futures are slipping 0.4%. On Tuesday, the Dow Jones Industrial Average rose 10 points, or 0.02%, to 44922,

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Futures tracking Canada's main stock index were flat on Wednesday, as investors await the U.S. Federal Reserve's annual symposium later this week for clues on the monetary policy path.

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Crude futures settled higher amid a lull in Russia-Ukraine news, with gains supported by a bigger-than-expected weekly decline in U.S. crude oil stocks.

Follow all the latest U.S. market action for Wednesday here to see if this week's selling of Ai-related technology names continues, and as Target gives clues on consumer spending.