A new review proposes that tRNA-derived small RNAs link chronic cellular stress to maladaptive translational remodeling in ...
Evolutionary changes in a key protein synthesis enzyme, isoleucyl-tRNA synthetase (IleRS), may help bacteria fine-tune how ...
A methylation mark on translation factor eEF1A selectively speeds decoding of rare, wobble-weak codons, boosting KRAS ...
23don MSN
Key driver of aggressive prostate cancer identified, suggesting new way to reverse drug resistance
Researchers at Fred Hutch Cancer Center have identified a previously overlooked molecular regulator that helps determine whether prostate tumors remain sensitive to treatment or evolve into a more ...
Evolutionary changes in key protein synthesis enzyme, isoleucyl-tRNA synthetase (IleRS), may help bacteria fine-tune how quickly proteins are made ...
RNA (ribonucleic acid) is a nucleic acid polymer where the carbohydrate is ribose. RNA is generally single-stranded, as DNA is transcribed by RNA polymerases into mRNA (messenger RNA), which is read ...
Researchers identified RNA-associated amyloid fibrils in human seminal fluid and demonstrated that synthetic PAP fibrils ...
The doctoral program is primarily designed to prepare its graduates for careers in both the academic field and scholarly research, including research-informed translation. It offers individualized ...
引言前列腺癌治疗中一个棘手的问题是：肿瘤最初高度依赖雄激素受体（androgen receptor, AR），但在持续的AR通路抑制压力下，一部分肿瘤会逐渐摆脱这种依赖，甚至转向具有神经内分泌特征的状态。这个过程被称为谱系可塑性（lineage plasticity），也是晚期前列腺癌产生治疗耐药的重要机制。近日，《Nature》的研究报道 ...
Angelman综合征（Angelman syndrome，AS）是一种严重的神经发育障碍，由UBE3A缺失所致，该基因编码一种E3泛素连接酶（E3 ubiquitin ligase）。目前对AS机制的理解仍不充分，尤其是UBE3A底物与疾病表型之间 ...
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