Tampa Bay Buccaneers quarterback Baker Mayfield started to make his case for the NFL MVP award with a huge win over the San Francisco 49ers.

It was all about defense today as the Broncos (4-2) rode nine sacks to a 13-11 win over the Jets at Tottenham Hotspur Stadium in London. Denver leads the AFC West for now by 1/2 game. The Jets (0-6) are still winless.

New York's offense as an epic disaster on Sunday in London, with the "passing" game in particular stinking up the joint. Fields dropped back to pass 29 times but only actually attempted 17 passes, because he was sacked NINE times and scrambled a few more.

The Seattle Seahawks are seeking their second-straight victory against an AFC South opponent in the Houston Texans. This rare matchup between these teams will take place on Monday Night Football, where the Seahawks own the NFL's record for best win percentage all-time at .705.

Sam Darnold and Co. defeated the Jaguars in Jacksonville, 20-12, behind a dominant defensive performance. Trevor Lawrence was sacked seven times, and the Jags rushed for just 3.1 yards per attempt. Darnold had 295 pass yards and two touchdowns -- including a 61-yard bomb to Jaxon Smith-Njigba.

Week 6 of the NFL Regular Season saw multiple players from Hawaii take to the field, including a matchup between 2018 HHSAA State Championship Game Opponents. Pittsburgh Steelers faced off against the Cleveland Browns on Sunday.

Sam Farmer makes his picks and predictions for Week 6 of the NFL season, with the Lions defeating the Chiefs in prime time and the Seahawks improving to 4-2.

Looking for a Week 6 QB streamer? Matthew Stafford is your guy. The NFL's leading passer generally maxes out as a fringe QB1 due to his rushing limitation (-4 yards this season), but he's set up with an elite matchup against an injury-ruined Ravens defense ...

A total of 10 games will be played as part of the NFL's Sunday afternoon slate in Week 6. Here's a look at which ones will be on in each region.