San Francisco has been up and down all season ... Check out expert picks and best bets for every NFL game this week. Buffalo had its bye and the 49ers are so banged up that it’s tough to back them in this spot — especially cause the Bills are hitting ...

The San Francisco 49ers are 5-6 entering their matchup with the Buffalo Bills on Sunday, and an NFL executive called out 49ers HC Kyle Shanahan for mishandling late-game situations. Colin Cowherd discusses this criticism and if it’s the biggest issue the 49ers have right now.

We thought San Francisco was poised for a massive second-half run after the Week 9 bye with Christian McCaffrey back, but the 49ers haven't looked good over their last three contests.  It wasn't a surprise the 49ers fell to the Green Bay Packers on Sunday with so many key contributors out.

One NFL team executive believes the San Francisco 49ers' 5-6 record is partially a product of Kyle Shanahan's coaching. "It's a combination of injuries

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NFL Week 13 odds, picks, predictions, TV and streaming information for Sunday Night Football game between the San Francisco 49ers and Buffalo Bills.

The Dolphins defense has been a bright spot so far in 2024 and this offseason they are predicted to add a key piece from the NFC.

The San Francisco 49ers face a tough challenge on Sunday, traveling to Wisconsin to take on the Green Bay Packers.

The San Francisco 49ers have let their 2024 season get away from them and now last year's NFC champions have their backs against the wall when it comes to makin

The Detroit Lions shed their laughingstock label over the previous two seasons. They just missed the playoffs in the 2022 season and then nearly reached the first Super Bowl in franchise history last season, winning the NFC North and reaching the conference championship game before squandering a 17-point lead to lose to the San Francisco 49ers.