Structurally, they look similar: MNK1 and MNK2 belong to the same enzyme family and are best known for regulating how cells ...

Researchers at The Wistar Institute have engineered a small-molecule drug conjugate that has directed an Aurora kinase A inhibitor into tumours via heat shock protein 90 targeting, increased ...

Few effective treatments exist to treat neurodegenerative diseases such as Alzheimer's disease (AD), Parkinson's disease (PD), and amyotrophic lateral sclerosis (ALS). 1 Existing treatments focus on ...

Protein kinase inhibitors represent a major advance in cancer treatment due to their ability to target the specific kinases involved in tumor growth and survival. More than 80 small-molecule protein ...

A new study reveals that the twin enzymes MNK1 and MNK2 play distinct roles in the brain, with one governing memory and the other social behavior.

BACKGROUND: BCR-ABL tyrosine kinase inhibitors (TKIs) have been increasingly linked to pulmonary arterial hypertension (PAH) since 2009, although supporting evidence is limited. Our objective was to ...

The choice of frontline therapy for a patient with chronic phase chronic myeloid leukemia (CP-CML) can have a profound effect on the long-term clinical outcome. Currently, five tyrosine kinase ...