Variable number tandem repeats (VNTRs) were among the first genetic markers used to quantitate bone marrow transplant engraftment. The limitations of PCR-based VNTR markers in distinguishing some ...
Abstract: Chimerism analysis is a surrogate indicator of graft rejection or relapse after allogeneic hematopoietic stem cell transplantation (HSCT). Although short tandem repeat PCR (STR-PCR) is the ...
We have recognized a number of problems, inherent in the STR-PCR technology, which may affect the eligibility of markers for chimerism testing and the accuracy of quantitative analysis. These are as ...
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