Sample preparation is essential when employing chromatography for bioanalytical analysis as system performance will be negatively affected if it is not performed. Preparation methods include protein ...

Top-down proteomics using mass spectrometry facilitates the identification of intact proteoforms, that is, all molecular forms of proteins. Multiple past advances have lead to the development of ...

Water freeze-drying has traditionally been considered an inappropriate drying method for biological samples for scanning electron microscopy (SEM) because ice crystals can potentially form and damage ...

The proteins that make up our cells hold within an entire world of information, which, when unlocked, can give us insights into the origins of many essential biological phenomena. This information is ...

Four principal methods govern the preparation of samples for XRF analysis, each representing a different trade-off between analytical quality and speed/cost of preparation. A method involving the ...

Although next-generation sequencing (NGS) keeps giving—exploring the human genome and revolutionizing our knowledge of health and disease—it needs to take a little, too. At the very least, NGS ...

Running samples on any chromatography instrument involves sample preparation as a fundamental process. For even the highest quality instruments, sample clean-up is crucial in obtaining the best ...

Sampling (including transport) and sample pooling. Preventing contamination, including contamination of the laboratory equipment and the environment with viral RNA. Manual extraction of RNA, automated ...

Protocols.io is an online platform designed for researchers to share their lab protocols and methodology as step-by-step instructions. Here, we share some of their latest protocols for preparing ...

Atomic force microscopy (AFM) is a very popular analysis tool for 3D surface topology visualization and other measurements on a wide range of materials at nanoscales ...

For XRF analysis, fused bead creation via fusion provides a nearly perfect, homogeneous sample representation. This method is ideal for solid samples. Gas and electric fusion machines can be used to ...

Single-cell proteomics provides information about a cell at its protein level, which can prove useful for anticancer drug resistance and cell differentiation research. However, current proteomics ...