Nearly two decades after the discovery of knotted proteins, most researchers think the strangely tangled molecules are too unwieldy to play much part in a cell's activities. This notion is changing.

Tie a trefoil knot in a piece of string, seal the ends together, and try to wiggle it free without cutting. In three-dimensional space, the knot holds firm. Add a fourth spatial dimension, however, ...

Proteins are long chains of amino acids that are essential building blocks for all living things. These chains form complex three-dimensional shapes that play a key part in their function—when ...

While excavating an Inca outpost on Peru’s southern coast, archaeologist Alejandro Chu and his colleagues uncovered some twisted surprises. In 2013, the scientists were digging in one of four rooms ...