Integrins are heterodimeric transmembrane receptors that orchestrate cell adhesion by linking the extracellular matrix and neighbouring cells to the cytoskeleton. In the immune system, integrins ...

Integrins are heterodimeric receptors that anchor cells to the extracellular matrix (ECM) and coordinate bidirectional signalling to regulate adhesion, migration, proliferation and differentiation.

Cells form adhesion structures to anchor themselves in their environment. The coordinated assembly and disassembly of these adhesions also enables cells to move from one place to another. There are ...

“Focus has been on how cells become mechanosensitive, how cell adhesion became mechanosensitive through the recruitment of mechanosensitive proteins like talin, vinculin, and also other proteins,” ...

Protein evolution occurs slowly via small incremental mutations—usually. However, dramatic changes can happen: for instance, a fragment of one protein getting copied into the middle of another. While ...

Research teams are analyzing how proteins work together to enable our cells to both stick and move. The marker protein paxillin is at the center of their interest. The tissue in our body can only hold ...

The tissue in our body can only hold together if the cells adhere not only to each other, but also to extracellular structures, such as collagen fibers of the connective tissue and the skin. How ...