C&EN

Opioid receptor agonists take advantage of new understanding of GPCR biology

Opioid receptors are fantastic targets for treating pain—but unfortunately, the drugs that target them can be addictive. Because the molecules suppress breathing and heart function, those drugs can ...
Nature

Large scale investigation of GPCR molecular dynamics data uncovers allosteric sites and lateral gateways

G protein-coupled receptors (GPCRs) constitute a functionally diverse protein family and are targets for a broad spectrum of pharmaceuticals. Technological progress in X-ray crystallography and ...
Nature

Functional dynamics of G protein-coupled receptors reveal new routes for drug discovery

G protein-coupled receptors (GPCRs) are integral membrane proteins responsible for transducing a broad range of signals from the extracellular environment to inside the cell. They represent the ...
FierceBiotech

Septerna snags $150M series B for pipeline of GPCR therapies tackling hard-to-drug targets

Septerna will use its $150 million fundraise to push forward an oral small-molecule PTH1R agonist. (iStock / Getty Images Plus) Septerna has secured $150 million in a series B fundraise, money that ...