One week after some stunning developments, like the New York Giants stunning the rival Philadelphia Eagles with a prime-time upset; and fresh off even more recent surprises, like the Joe Flacco-led Cincinnati Bengals outdueling the Aaron Rodgers-led Pittsburgh Steelers,

The 49ers (4-1) travel across the country to face the Bucs (4-1), and both teams are coming off entertaining 3-point wins on the road. The 49ers — despite being riddled with injuries on offense — won Thursday night over the Rams as huge underdogs. Mac Jones filled in again for quarterback Brock Purdy and the 49ers offense looked good.

Strahan isn't alone either, as ESPN BET gives Mayfield the second-best odds (+325) to win MVP, behind Kansas City Chiefs quarterback Patrick Mahomes (+175). Buffalo Bills quarterback Josh Allen also stands at +325.

The Rams beat the Ravens last week, while the Jaguars lost to the Seahawks. The Seattle line sacked Trevor Lawrence seven times in that game. The Rams' defensive front has to be licking its chops. The Los Angeles offense will be without Puka Nacua, its best receiver. That matters. The Jaguars will pull one out late.

"FOX NFL Sunday" crew give their pick on who is the best NFL team is, NFL on FOX insider Jay Glazer reveals which former NFL champion will come out of retirement.

Learn more about for Jalen Hurts' prop betting lines, stats and more before his Philadelphia Eagles play against the New York Giants in a Week 8 NFL

The SportsLine projection model has revealed its Los Angeles vs. Minnesota picks for the 2025 NFL Week 8 'Thursday Night Football' game