Eliciting or boosting T cell recognition of cancer cells has led to major clinical breakthroughs. Immune checkpoint inhibitors, which consist of antibodies that block inhibitory receptors expressed on ...
The monomorphic antigen-presenting molecule CD1d presents lipid antigens to both αβ and γδ T cells. While type I natural killer T cells (NKT) display exquisite specificity for CD1d presenting ...
The research team engineered CD8+ Jurkat T cells to express SVAR16, a human TCR with intermediate-to-high 2D affinity for the SARS-CoV-2-derived epitope HLAA2:01–YLQ, using lentiviral transduction.
Cells aren’t as passive as scientists once thought—they actively create internal currents to move proteins quickly and efficiently. These “cellular winds” push materials to the front of the cell, ...
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