Prior to this study, euchromatin was thought to have an open, or less condensed, conformation to allow the large proteins associated with gene transcription access to genomic DNA. Instead, the ...

Scientists studying cells have long held the view that euchromatin, the part of chromatin that is made up of genes and is genetically active, is open and can be transcribed. A research team, looking ...

Live-cell super-resolution imaging in human cells shows that active euchromatin forms compact dynamic domains and that the cohesin complex prevents their local mixing, preserving transcriptional ...

The human genome is about two meters long, yet it is folded inside a cell nucleus only about 10 micrometers in diameter. To fit into this tiny space, DNA is wrapped around histone proteins to form ...

To fit the two-meter long DNA molecule into a cell nucleus that is only a few thousandths of a millimetre in size, long sections of the DNA must be strongly compacted. Epigenetic marks maintain these ...

To coordinate the coding complexity of the eukaryotic genome, mechanisms have evolved that protect active genes from silent chromatin structures such as heterochromatin. Although post-translational ...

The physical characteristics of actively expressed chromatin, or euchromatin, remain a mystery. Recent research suggests that euchromatin mainly contributes to gene regulation in a condensed state, ...

In their paper the team discusses their novel view of euchromatin in the cell and shows how the revealed organization is relevant to genome functions. “Our ultimate goal is to reveal how genomic ...