A team led by scientists at The Scripps Research Institute (TSRI) has determined the basic structural organization of a molecular motor that hauls cargoes and performs other critical functions within ...
The structural basis of processive stepping by cytoplasmic dynein has not previously been investigated. Understanding of myosin-5’s movement along actin filaments was greatly aided by visualizing it ...
Cytoplasmic dynein associates with dynactin to drive cargo movement on microtubules, but the structure of the dynein–dynactin complex is unknown. Using electron microscopy, we determined the ...
A team led by scientists at The Scripps Research Institute (TSRI) has determined the basic structural organization of a molecular motor that hauls cargoes and performs other critical functions within ...
Nearly 50 years after the discovery of the walking molecular motor dynein, researchers have finally solved the first X-ray crystal structure of its massive motor domain. The milestone will permit ...
Measuring only 50 nanometers, dynein can carry its cargo up to a metre in humans - the equivalent of humans walking about forty thousand kilometres. Dynein is poorly understood, partly because it is ...
What is the dynein-dynactin complex and where is it found? What functions is this molecular motor thought to perform within cells? This is a macromolecular assembly is made up of two components, ...
Our cells rely on microscopic highways and specialized protein vehicles to move everything—from positioning organelles to carting protein instructions to disposing of cellular garbage. These highways ...
Oregon State University scientists have taken a key step toward better understanding neurodegenerative diseases by using a suite of biophysical techniques to learn more about a motor protein whose ...
Researchers capture first-of-its-kind video of dynein–Lis1 protein interaction, supporting future drug development for neurological disorders. Our cells rely on microscopic highways and specialized ...
Scientists have determined the basic structural organization of a molecular motor that hauls cargoes and performs other critical functions within cells. The complex's large size, myriad subunits and ...
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