A study points to the possibility that thalidomide derivatives are potentially suitable for treating cancer. Thalidomide was marketed in the 1950s as a sleeping pill. It later gained sad notoriety for ...
In a recent study published in Scientific Reports, researchers designed substituted spiro indolin-1,2-diazepine derivatives '5a–v' with cholinesterase (ChE) inhibitory activities as anti-Alzheimer's ...
The thalidomide derivatives C5, C6 and C7 alter CRBN – the “labeling machine” – so that it can bind to BCL-2. In this way, the BCL-2 molecule is marked for degradation – a possible new strategy ...
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