Antibodies are essential for immune defense and safeguarding against bacteria, viruses, and other foreign entities. Produced by B cells, these protein molecules offer the potential for treating ...

Antibody- and cell-mediated immunity is known to be key to overcoming the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the agent that has caused the coronavirus disease 2019 (COVID-19 ...

The authors found that Csk (a tyrosine kinase that attenuates B cell receptor signaling) is required for germinal center maintenance and efficient antibody maturation. Osaka, Japan – The immune system ...

Characterization of protein–protein binding is a critical element in the development of therapeutic antibodies. The desirable characteristics of effective therapeutic antibodies often include a high ...

It stands to reason that vaccine-mediated disease enhancement can occur only if a vaccine fails to elicit high-affinity neutralizing antibodies that prevent infection. However, contrary to the authors ...

Proteasome assembly is a complex process, requiring 66 subunits distributed over several subcomplexes to associate in a coordinated fashion. Ten proteasome-specific chaperones have been identified ...

Antibodies play a vital role in the immune system by providing protection against foreign invaders, such as bacteria and viruses. Produced by B cells, antibodies are protein molecules that can be ...

Antibody humanization and affinity maturation have revolutionized the biotech industry in the past 10–20 years, enabling the development of highly effective therapeutic antibodies that can be used to ...