Catholic cardinals are gathering at the Vatican to elect the successor to Pope Francis, who died on April 21. Voting will take place in the Sistine Chapel, with ballots continuing in succession until any candidate secures two-thirds of the available votes.

The first papal conclave in 12 years begins on Wednesday at the Vatican after a morning Mass in St. Peter’s Basilica. At 4:30 p.m. local time (10:30 a.m. Eastern), the cardinals will walk in a short procession to the Sistine Chapel from the nearby Pauline Chapel to begin the vote.